
Public health officials in California have confirmed that three individuals in Mammoth Lakes have died from hantavirus, a serious rodent-borne illness that has previously claimed the life of Betsy Arakawa, the wife of actor Gene Hackman. The alarming news was reported by NBC News on April 18, 2025.
The Mono County health officials issued a statement highlighting the situation as ‘tragic’ and ‘alarming’. Despite the low occurrence of hantavirus, the quick succession of cases has raised concerns about potential outbreaks under such conditions.
‘The occurrence of three cases in a short period has me worried, especially this early in the year,’ said Dr. Tom Boo, the county public health officer. Hantavirus, which is typically transmitted through contact with rodent excretions, usually emerges later in spring and summer, making this early surge particularly concerning.
The third reported death occurred recently, with the individual being a young adult whose infection source has yet to be identified. Dr. Boo noted, ‘The home had no evidence of mouse activity. However, there were some mice observed at the workplace, which is common for indoor spaces at this time of year.’
Even though deer mice are prevalent in California’s Eastern Sierra region, it is suspected that their populations are unusually higher this year, which may increase the risk of hantavirus exposure.
In a tragic coincidence, the latest death follows the February death of Betsy Arakawa, who, alongside her husband, was found in their home in Santa Fe, New Mexico. Although Gene Hackman tested negative for the virus, authorities confirmed his death was due to natural causes, while Arakawa’s case was linked to hantavirus pulmonary syndrome.
Symptoms of hantavirus include fatigue, fever, muscle aches, and more severe reactions involving respiratory issues. Dr. Boo stressed the importance of being vigilant, especially around areas with potential mouse droppings, stating that healthy practices concerning the presence of rodents should be observed during this period.
‘We’ve now gone about a month without any additional suspect cases, but remain concerned about the increase in activity,’ he added, emphasizing public awareness and caution.

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